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Genetic Familial Hypercholesterolaemia Risk

£599

Genetic Familial Hypercholesterolaemia Risk

Description:

Genetic Familial Hypercholesterolemia (FH) Risk Test analyses your DNA to assess your likelihood of inheriting this condition. FH is a genetic disorder causing high levels of "bad" cholesterol (LDL) in the blood.

Gene List:

APOB - The APOB gene plays an important role in cholesterol transport throughout the body. Mutations in this gene can lead to a variety of health problems, including familial hypercholesterolemia, a condition that causes high levels of LDL cholesterol in the blood.

APOE - The APOE gene governs the production of a protein called apolipoprotein E, which is crucial for fat metabolism in your body. APOE variations can be linked to Alzheimer's, anxiety and depression.

LDLR -

The LDLR gene is like a blueprint for a critical protein called the low-density lipoprotein receptor (LDLR). This receptor plays a key role in managing cholesterol levels in your blood.

LDLRAP1 - LDLRAP1 acts as a supporting player to LDLR, ensuring efficient processing of LDLs and maintaining healthy cholesterol balance. Mutations in this gene can disrupt this process and contribute to certain cholesterol disorders.

PCSK9 -  This gene encodes a protein called proprotein convertase subtilisin/kexin type 9. PCSK9 plays a critical role in regulating cholesterol levels by affecting LDLR, the LDL receptor you learned about earlier. Unlike LDLR and LDLRAP1 which directly remove LDL cholesterol, PCSK9 works in the opposite way. It targets LDLR for degradation, essentially reducing the number of LDL receptors available to grab LDL particles from the bloodstream.

Turnaround times:

Turnaround Time: 

  • 7 Days


Note:

This service is only available to the age of 16 and above.


Furthermore, Any Cancellation within 48 hours prior to appointment will incur a charge of 20% of total service cost.




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