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What is it?
Polynucleotide treatment is a non-invasive, injectable skin therapy aimed at rejuvenating and repairing the skin. It uses polynucleotides—naturally derived DNA fragments—to stimulate cell regeneration, improve skin hydration, and enhance elasticity. These agents help to attract water molecules to the skin, boosting hydration levels while also promoting collagen production.
For this reason, polynucleotides are defined as bio-restructuring compounds, that not only nourish and protect cells, but above all stimulate an increase in production and efficient reproduction thus considerably reducing the aging process
ProcedureWhat does it help with?
Early signs of aging
Dull, dry, or dehydrated skin
Poor skin texture and tone
Loss of skin elasticity
Product administered
We use the Plinest range for this treatment, manufactured by Mastelli—the original pioneers of polynucleotide therapy. Plinest is an excellent all-rounder, focusing heavily on improving overall skin texture, deep hydration, and preventing early signs of ageing. The different formulations include:
Plinest: The original and most versatile formulation, ideal for overall facial rejuvenation, deep hydration, and improving skin elasticity and texture in mature skin.
Plinest Fast: A lighter formulation designed for younger skin as a preventative measure against ageing, or for treating more delicate areas of the face and body.
Plinest Eye: Specifically formulated for the highly delicate periorbital area to improve skin quality, boost hydration, and reduce the appearance of tired eyes.
Polynucleotides - Comparison Table
Below is a comparison of the most widely used polynucleotide treatments, outlining the specific features and best uses for each:
Polynucleotides – Comparison Table
Feature | Lumi Eyes | Nucleofill | Rejuran | Plinest |
What it does | Hydrates and brightens under-eyes | Firms and rebuilds ageing skin | Repairs and heals damaged skin | Improves skin texture and hydration |
Best for | Dark circles, tired eyes | Loose skin, fine lines | Acne scars, sensitive or damaged skin | Early ageing, dull or dry skin |
Under-eye use | Yes (main use) | Yes | Yes | Yes |
Lifting effect | Low | High | Mild | Mild |
Skin repair | Mild | Moderate | Strong | Moderate |
Downtime | Very little | Mild swelling/bruising | Slightly more (small bumps possible) | Very little |
How long it lasts | 4–6 months | 6–9 months | Around 6 months | 4–6 months |
Timeline and Expected Results
Typically, the effects of Plinest treatments last for about 4 to 6 months. For the best outcome, a course of 3 to 4 sessions spaced roughly 3 weeks apart is usually recommended.
Procedure
The procedure involves the micro-injection of a polynucleotide solution into the dermis or subcutaneous tissue using fine needles, with cannulas occasionally used for delicate areas like under-eyes to minimize bruising. The treatment is minimally invasive, with injections targeting specific areas to promote skin rejuvenation.
Appointment duration
60 mins
Note
This service is exclusively for individuals aged 18 and over.
During booking, only a £30 deposit is required for the initial consultation, which will be deducted from the total treatment cost. The remaining payment will be collected at a later stage.
If you require treatment for multiple areas, please fill out an enquiry form by clicking here, and we can offer you a more cost-effective quote.
Any cancellation, rescheduling, or missed appointment within 48 hours of the scheduled time will result in the loss of the £30 deposit. If you wish to reschedule, a new £30 deposit will be required to secure the new appointment.